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Adiponectin Receptor

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By Targets:	Adiponectin Receptor (4) Adrenergic Receptor (2) Autophagy (2) GLUT (1) Insulin Receptor (1) NF-κB (1) P2X Receptor (1) p38 MAPK (1) PPAR (1) Reverse Transcriptase (2)
By Research Areas:	Cancer (3) Endocrinology (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (5)

6

Inhibitors & Agonists

4

Natural
Products

3

Recombinant Proteins

2

Antibodies

Targets Recommended: Adiponectin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

AdipoRon Maximum Cited Publications 20 Publications Verification	Adiponectin Receptor	Metabolic Disease
AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K_ds of 1.8 and 3.1 μM, respectively.

Gramine 2 Publications Verification Donaxine	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 µM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic receptor* (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Zeaxanthin dipalmitate Physalien	Adiponectin Receptor P2X Receptor Autophagy	Inflammation/Immunology
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

PPARγ/δ modulator 1	PPAR	Metabolic Disease
PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with K_i values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC₅₀ of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively .

Gramine (Standard) Donaxine (Standard)	Adiponectin Receptor Adrenergic Receptor Reverse Transcriptase	Infection Metabolic Disease Endocrinology Cancer
Gramine (Standard) is the analytical standard of Gramine. This product is intended for research and analytical applications. Gramine (Donaxine) is a natural alkaloid isolated from giant reed , acts as an active adiponectin receptor (AdipoR) agonist, with IC₅₀s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively . Gramine is also a human and mouse *β2-Adrenergic receptor* (β2-AR)** agonist . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties .

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

Species:	Human (3)
Tag:	His (2) SUMO (1) Tag Free (1) Myc (1) Flag (1)
Source:	E. coli Cell-free (3)

Cat. No.	Compare	Product Name	Species	Source

	ADIPOR1 Protein, Human (Cell-Free) Adiponectin Receptor protein 1; Progestin and adipoQ Receptor family member 1; Progestin and adipoQ Receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with tag free. The total length of ADIPOR1 Protein, Human (Cell-Free) is 287 a.a., with molecular weight of 33.0 kDa.

	ADIPOR1 Protein, Human (Cell-Free, His, Flag) Adiponectin Receptor protein 1; Progestin and adipoQ Receptor family member 1; Progestin and adipoQ Receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free, His, Flag) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with N-6*His, N-Flag labeled tag. The total length of ADIPOR1 Protein, Human (Cell-Free, His, Flag) is 287 a.a., with molecular weight of 34.8 kDa.

	ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) Adiponectin Receptor protein 1; Progestin and adipoQ Receptor family member 1; Progestin and adipoQ Receptor family member I	Human	E. coli Cell-free
	ADIPOR1 Protein, a receptor for adiponectin (ADIPOQ), crucially regulates glucose and lipid metabolism, maintaining homeostasis and healthy body weight. Upon ADIPOQ binding, ADIPOR1 activates AMPK, promoting fatty acid oxidation and glucose uptake while inhibiting gluconeogenesis. ADIPOR1 interacts with APPL2, negatively regulating signaling, and with APPL1, enhancing ADIPOQ-induced recruitment and positive regulation of adiponectin signaling. ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived ADIPOR1 protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of ADIPOR1 Protein, Human (Cell-Free, His, SUMO, Myc) is 375 a.a., with molecular weight of 62.6 kDa.

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